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At 6 weeks post-TAC surgery, echocardiography analyses of these mice revealed that TAC-operated animals exhibited significant reductions in EF and FS relative to sham control mice, whereas IVSd, LVIDd and LVIDs were increased, while PQQ treatment partially reversed this TAC-induced cardiac dysfunction (Figures 1BE)

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10.1067/mcp.2000.104736 54 MazaleuskayaL