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However, the results of the force sensor assay in Drosophila lead us to favor the view that membrane association per se potentiates ligand activity, and raises the possibility that nonspecific endocytic processes such as macropinocytosis or micropinocytosis are sufficient to generate a pulling force (Figure 4)

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hold a published patent (WO/2023/180570) that covers the in vitro method for identifying anti-senescence compounds based on detecting the binding of said compound in the presence of at least one phosphorylated amino acid in the transcription activation domain (TAD) domain of mammalian protein p53

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Lin et al., 2018)

10.1016/j.trci.2018.03.009 51 DadarM.ShahaliY.ChakrabortyS.PrasadM.TahooriF.TiwariR.et al (2019)