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How Are GLP-1s Taken

Short answer: We simply dont know long-term

oral administration of LAC leads to a significant increase in LAC concentrations in both plasma and cerebrospinal fluid (CSF) [33], showing that LAC crosses the bloodbrain barrier and reaches the brain at significant concentrations

First, we considered the possibility that responses mediated by GLP-1R might be modulated by the state of the Y1-R

(Ansari et al