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58 SIRT6 is known to have chromatin regulatory activity in telomeres, and deletion of SIRT6 causes genomic instability and premature cell senescence in primary human fibroblasts due to telomere dysfunction

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For preclinical tissue models, stronger evidence would require standardized injury models, blinded outcome assessment, histological confirmation, functional endpoints, and comparison against appropriate positive and negative controls

10.1186/s13148-021-01064-y 29 ParkH.KimM.RothenbergerC.KumarA.SampsonE

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