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161 During aging, diverse cellular and environmental stresses are known to cause cellular senescence and chronic inflammation, both of which stimulate the release multiple inflammatory cytokines, such as IL1, IL6, and TNF, promoting further tissue damage
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It is often used to justify a diagnostic colonoscopy following a positive screening test
Altered intestinal permeability (leaky gut) allows the passage of food antigens, toxins, bacteria, and microbial products, promoting inflammation and dysregulated immune responses, triggering autoimmunity through various mechanisms [188]
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