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Neurological: Numbness or tingling in the extremities (paresthesias), difficulty walking, balance problems, muscle weakness, vision problems, cognitive disorders (difficulty concentrating, memory loss), mood changes (depression, irritability)

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Archives of General Psychiatry, 56(1), 29-36

This remains an actively moving area, however: on February 27, 2026, the HHS Secretary publicly announced an intent to move roughly 14 of the 19 Category 2-listed peptides, reportedly including ipamorelin and CJC-1295, back toward Category 1 status, and multiple industry and legal-news outlets reported further FDA action in the following months easing Category 2-related restrictions on this group of peptides

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