While previous research has predominantly focused on the role of individual proteins in response to H 2 O 2 exposure [16, 24], only one proteomic study examined the global changes in chondrocytes exposed to both H 2 O 2 and hyaluronic acid in 2014, identifying a limited number of protein targets [25]
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TABLE 2 Pharmacological therapies for osteoarthritis: clinical use, evidence, and limitations