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Figure 2 2 Data of efficacy 2.1 Clinical trials: the SURPASS program The central clinical trial program designed to demonstrate the therapeutic effectiveness (in terms of GC and BW reduction), tolerability and safety of TZP in diabetic patients was the SURPASS program

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These include orlistat, phentermine-topiramate (FDA-approved only), naltrexone-bupropion, liraglutide, setmelanotide, semaglutide, and tirzepatide [9, 10]

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Fermentable fibers can raise the bodys own GLP-1 through short-chain fatty acid signaling and improve satiety and glucose control, but their standalone weight-loss effect is small, on the order of 0.3 to 0.8 kg versus control, compared with 10 to 20 kg or more for the drugs

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