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BMJ Open 9 (4), e025722

Because of the larger atomic radius of selenium compared to sulfur, selenium is more polarizable (softer) than sulfur, allowing intrinsic selenium to be more nucleophilic and electrophilic 61,62

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Abstract Nephropathic cystinosis is a lysosomal storage disease due to biallelic pathogenic variants in the CTNS gene encoding the cystine transport protein cystinosin