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To test this hypothesis, we initially injected control and -barr1-KO mice with glibenclamide (5 mg/kg i.p.) or tolbutamide (25 mg/kg i.p.), 2 commonly used SU drugs

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I also remember that Valter Longo suggests an optimum IGF-1 of 140 ng/ml, which constitutes just the punctual optimum in that metanalysis

The critical next step is to investigate these combinatorial interactions