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Without nitric oxide, there is a reduction in blood flow, and therefore, a reduction in the amount of oxygen actually reaching body tissues

This will only accelerate as we see an explosion of generics and me-toos crushing the cost-curve

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An example of how our understanding of molecular mechanisms can be expanded by mouse models comes from the COL3A1 knockout mouse (29)

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66,67 Farnesoid X receptor (FXR), Wnt, and bone morphogenetic protein have also been shown to contribute to LPC differentiation into hepatocytes