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Route of administration changes the result: supervised subcutaneous injection of 503A compounded GHK-Cu produces systemic and targeted effects that topical serums cannot replicate

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Therefore, adjusting the cargo of exosomes and/or engineering their spreading pathways could target cancer cells (especially CSCs) or the TME in order to induce ferroptosis, thus achieving a positive therapeutic outcome

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MDA is a product of lipid peroxidation and an indicator of oxidative stress, while GSH is a vital antioxidant that plays a crucial role in cellular defense mechanisms