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They are derived from the posttranslational processing of three preprotachykinin precursors: preprotachykinin A, consisting of substance P (SP), neurokinin A (NKA), neuropeptide K (NPK) and neuropeptide- (NP)

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Now called Chronic Lyme is Post-Treatment Lyme Disease Syndrome (PTLDS), PTLDS is characterized by persistent symptoms after an appropriately treated Lyme disease infection