Bacteria (and viruses, and spores, etc) are invisible to the naked eye
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[17] Eli Lilly and Company, 'Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)', ClinicalTrials.gov identifier NCT06260722
That is harder to answer in a simple way, because tolerability varies from person to person