This protective effect was primarily driven by a 30% reduction in liver decompensation events, comprising ascites, hepatic encephalopathy, variceal bleeding, and hepatorenal syndrome (IRR: 0.70, 95%CI: 0.52-0.94, P = 0.020), based on six studies comprising 877,488 participants
Change the injection site each time to prevent irritation and reduce the risk of skin site infections
21 In clinical practice, pharmacists can apply this approach by counseling patients on how to monitor for GI AEs and how this correlates with appropriate dose escalation
"I trained at the highest level, ate a clean diet, pushed myself, and still, after having kids, my body just wouldn't respond
Clinical trials of GLP-1 medications, including the STEP program for semaglutide and SURMOUNT trials for tirzepatide, have documented improvements in physical function scores and quality of life measures
Interestingly, recent studies have found that chronic GLP-1R activation results in enhanced ATP production and upregulation of glycolytic enzymes which increases the potential of ATP production anaerobically