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This effect may be due either to inhibition of carbamyl phosphate synthase (CPS) I by -oxidation metabolites (CPS I is the first mitochondrial enzymatic step of the urea cycle) or to decreased synthesis of N -acetyl glutamic acid (NAGA) from acetyl-CoA and glutamate by NAGA synthetase (NAGA is an important cofactor of CPS I)

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In this review, we discuss research on the prevalence and regulatory mechanisms of ferroptosis, the effect of ferroptosis on the immune system, and the significance of ferroptosis in cardiovascular diseases