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The molecular mechanism of cognitive function broadly encompasses systems involved in neurotrophic signaling and neuronal metabolism as well as neuronal growth and survival [9, 10]

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2.1.3 Inhibited pyroptosis and inflammation of follicular granulosa cells Furthermore, researchers have discovered that metformin has the potential to enhance follicle development and induce ovulation by suppressing pyroptosis and inflammation of follicular granulosa cells

Some studies cited in a 2025 review noted that while proline can protect cells at low levels, when metabolized by the enzyme proline oxidase it produces reactive oxygen species (ROS)

Melatonin receptors: Role on sleep and circadian rhythm regulation