The two peptides target non-overlapping mechanisms, making the combination theoretically additive or synergistic rather than redundant
Specifically, in ischemic/high-ROS environments, BACH1 tends to be degraded and acts to suppress angiogenesis by inhibiting the Wnt/-catenin signaling pathway and recruiting HDAC1, among other mechanisms
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The pathway is sometimes referred to as a cycle, but according to its classical representation, it is a linear sequence that links reduction of H 2 O 2 , catalysed by APX, to oxidation of NADH or NADPH, catalysed by MDHAR and GR (Fig