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Dihexa offers a mechanistically intriguing but unvalidated probe for HGF/c-Met neurobiology, with the critical caveat that its core published evidence is under question

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[DOI] [PubMed] [Google Scholar] 51.Thareja S., Aggarwal S., Malla P., Haksar D., Bhardwaj T.R., Kumar M

Additionally, neurotoxins induce nuclear fragmentation, endoplasmic reticulum (ER) stress and unfolded protein response in catecholaminergic cells, which are associated with changes in proteasomal and chaperone activities, similar to those observed in PD [45,55]

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Data were described as the means SD of three independent experiments