When hepatocytes can no longer store copper adequately, toxic copper ions are released into the bloodstream and accumulate in other organs, increasing the risk of cell injury [27]
We chose to make all transport rates linear and adjusted them so that the measured APAP, APAP-S, APAP-G, and NAPQI-GSH concentrations in the plasma and the urine were as measured in the literature[4, 6, 11, 3032]
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A protocol that sounds logical online may not match the patients diagnosis