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Many users experience a significant boost in day-to-day energy, enabling a more active lifestyle

If you have diabetes and monitor your blood glucose, check your levels when experiencing these symptoms Gastrointestinal side effects (nausea, vomiting, diarrhoea, constipation) are severe or persistent, as these may require dose adjustment or additional management strategies Signs of pancreatitis develop, including severe, persistent abdominal pain radiating to the back, as this is a rare but serious adverse effect requiring immediate medical attention Upper-right abdominal pain occurs, which could indicate gallbladder diseasea known complication associated with GLP-1 receptor agonists and rapid weight loss Unexplained symptoms such as extreme fatigue, cold intolerance, or mood changes occur, which might indicate thyroid dysfunction or other metabolic issues affecting hunger Your healthcare provider may need to: Review your current dose and titration schedule Assess for potential drug interactions or contraindications Screen for underlying conditions affecting appetite (thyroid disorders, diabetes, depression) Evaluate your dietary intake and eating patterns Consider whether Wegovy remains the most appropriate treatment option Discuss combination approaches or alternative weight management strategies NICE guidance (TA875) recommends discontinuing GLP-1 receptor agonists for weight management if less than 5% weight loss is achieved after 6 months at the therapeutic dose, unless there are other clinical benefits

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Treatment discontinuation due to gastrointestinal events occurred in a minority of patients, and overall, serious adverse events were similar to those with the placebo

This is the first approval for an oral GLP-1 class obesity drug, marking a turning point in a market dominated by injectables

They're frequently studied together