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For the latter, some data show that diarrhea affects up to 10% of users

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The second pathway involves direct GHS-R1a receptor activation independent of the GH axis

[DOI] [PubMed] Costa A, Reyns B, Konieczna J, Martn M, Fiol M, Palou A, et al

Preclinical evidence provides a potential mechanism, with animal models showing that GLP-1RAs can reduce intraocular pressure by inhibiting sodium-potassium ATPase and enhancing nitric oxide synthesis [101]

however, cardiovascular risk reduction is not currently a licensed indication for Wegovy in the UK, and your GP or specialist will weigh the available evidence carefully in the context of your individual circumstances