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Inpanathan, S

We therefore suggest monitoring drug levels at least at the start of cotreatment with GLP1RAs, especially in patients with kidney dysfunction who are at risk for drug accumulation to toxic levels

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The abdomen also tends to have less nerve density than the thigh at the specific insertion points used, which translates to less sensation during injection

doi:10.1016/S2213-8587(21)00174-1

The main enzyme involved, dipeptidyl peptidase-4 (DPP-4) also known as CD26, cleaves off the two N-terminal residues resulting in GLP-1 (9-36 amide) which is inactive or acts as an inhibitor at the GLP-1 receptor (23)