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In humans and animals, it has shown no toxicity and good tolerability [23, 28]

For example, a 12-month study in older adults found MK-677 raised IGF-1 to youthful levels and increased lean body mass , with participants gaining muscle instead of losing it all with no serious side effects noted

The math is simpler for semaglutide because the doses are larger and easier to measure on standard syringes