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In an LPS-induced neuroinflammation model established by microinjecting LPS into the brains of four dpf larvae, pretreatment with hecubine for 24 h markedly reversed the LPS-induced upregulation of pro-inflammatory mediators, including inducible nitric oxide synthase ( iNOS ), tumor necrosis factor- ( TNF- ), interleukin-6 ( IL-6 ), and IL-1 (Li et al., 2024)

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Chen K, Song L, Jin MJ, Fan CH, Cao J, Yu WP

Episode 505

A few important reminders: This is a review, not an approval The FDA will make the final decision Patient safety, quality standards, and clinical evidence remain central to the discussion Whether you're a prescriber, pharmacist, or patient, this is a regulatory development worth watching

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