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First, the absence of human pharmacokinetic data means there is no established optimal dose
PMID 22961902
Yet enthusiasm must remain proportional to evidence - early trials are promising, but far from definitive
Moreover, the oncogenic KRAS protein can be released by ferroptotic pancreatic cells, promoting pro-tumor M2 macrophage polarization through uptake by the AGER/RAGE (advanced glycosylation end-product specific receptor) [211]
But like any therapy, how you use them is just as important as using them at all