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Next, I detail the physiology of incretin signaling across the gutbrainpancreas axisincluding slowed gastric emptying, central satiety regulation, glucose-dependent insulin secretion, and glucagon suppressionand link mechanisms to clinical results

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In in vivo models (DIO mouse, ZDF rat, GLP-1R-/- transgenic mouse) its effect on glucose homeostasis, body weight, lipid profiles, -cell function and markers of neurodegeneration and cardioprotection is studied

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