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People return to activity when pain decreases, yet the tissue may not have regained structural integrity

Biochem J 347:8217, PMID: 10769188 Pineda-Molina E, Klatt P, Vzquez J, Marina A, Garca de Lacoba M, Prez-Sala D, Lamas S (2001) Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding

A poor diet and lifestyle can deplete glutathione levels, as can smoking, toxins, stress and certain medications

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the interaction between FDXR and p53 can also inhibit tumor initiation and progression