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The high concentrations in platelets and leukocytes ensure that tissue injury and accompanied by platelet degranulation and immune cell infiltration and creates an immediate local concentration of Thymosin Beta-4 at the injury site, positioning it as an early-release local repair signal whose biology begins before transcriptionally regulated growth factor responses can establish themselves
Similarly, bivalent constructs (Sm14/Sm28 GST expressed in Escherichia coli , Sm14/Sm29, and FSm14/29 adjuvanted with poly(I:C), administered in murine models resulted in declines in adult worms, hepatic and intestinal eggs, and hepatic granuloma size and frequency, and elicitation of Th1 immune responses (87, 103106, 110)
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