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Conclusion Although the HbA1c level did not decrease significantly after 6 months of sitagliptin treatment, an increase in insulin secretion and reduction in early phase postprandial plasma glucagon-to-insulin ratio excursion was confirmed in Korean subjects with type 2 diabetes

Zheng N, Wang C, Li Y, Fu H, Hu T

Some researchers keep a simple log noting where each injection goes

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Dual receptor adaptation: Both GLP-1 and GIP pathways need gradual introduction GI tolerability: Your gut needs time to adjust to slowed gastric emptying Nausea prevention: Starting higher dramatically increases nausea and vomiting rates Dropout reduction: Gradual titration keeps more people on treatment long-term What to Expect at 2.5mg At the starting dose, you may notice: Mild appetite reduction (variable