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Through a variety of mechanisms, metabolic syndrome increases our risk for cardiovascular disease, which can manifest as both acute and chronic blockages in the arteries supplying blood to our heart, strokes, heart rhythm abnormalities, and heart failure (weakness and stiffness of the heart muscle). The GLP1 [weight loss] drugs are the best available medications for treatment of obesity
To establish the proportion of differentially expressed genes that were potentially regulated directly by GH, we compared the data by orthology with mouse genes identified as having STAT5 bound to putative regulatory elements by chromatin immunoprecipitation sequencing (ChIP:seq)
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