It promotes mitochondrial fatty acid oxidation and performs other biochemical functions, including acetyl buffering, maintaining sufficient coenzyme A concentrations in mitochondria during anaerobic energy production, stimulating the tricarboxylic acid cycle, and stimulating ATP export from mitochondria during sustained muscle exercise
EBioMedicine , 46 , 499511
& Wei, L
The causal relationship between zinc and osteoarthritis: a two-sample mendelian randomization study
Similarly, a randomised control trial in older adults with median age 73 years reported that supplementation of 500 mcg vitamin B12, 400 mcg folic acid and 15 mcg vitamin D3 for two years resulted in an average reduction of homocysteine by approximately -4.2 micro mol/L compared to the placebo group (De Koning et al, 2016)
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