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Presurgical T1w MRI scans and post-surgical CT images were co-registered through linear registration to localize the electrodes according to a previously reported procedure 125

TABLE 9 mean sting (after phlegm elimination to 60 minutes) Impact of trigeminal nerve Determination of the Total intensity of trigeminal sensory factor on Soft tissues of the oral Cavity for Compounds 102 and 103 and control Compound 1, including numbness, Cooling: ( Is not provided with Suction) of,Irritation, warmth, burning and stinging

doi: 10.1186/s12967-020-02455-0 9 JasonLARichmanJARademakerAWJordanKMPlioplysAVTaylorRRet al

Drug class: Benzodiazepine antagonist

Altogether, these findings indicate that the antioxidant effects of metformin are achieved by Nrf2 nuclear translocation, increased downstream cytoplasmic HO-1 expression, and the subsequent activation of Nrf2 dependent signaling pathway