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Glutamate is released at synapses throughout the brain, and exerts changes in postsynaptic excitability and neuroplasticity (68)

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The main mechanism is closely related to the expression of protein and mRNA of action factors

Real-time polymerase chain reaction (PCR) was performed by using a kit (SYBR Premix EX Taq, Takara Bio Inc.) and the ABI PRISM 7300 real-time PCR system

Both drugs share common, generally mild-to-moderate gastrointestinal side effects (nausea, vomiting, diarrhea) common to all incretin-based therapies

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