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This review systematically examines recent advances in the regulation of HF by gut microbiota metabolites, focusing on their bidirectional regulatory mechanisms

Phytic acid, as an example, impedes the absorption of iron, zinc, magnesium, calcium, and manganese by forming insoluble salts with the ionized minerals (121, 122)

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Success will depend on disciplined translational design, early integration of manufacturing and regulatory planning, and a realistic assessment of the competitive landscape