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The protocol has to account for elevated nervous system load meaning lower training volume, more sleep, and more conservative dose titration than premenopausal women

Weight loss and liver fat reduction were very tightly correlated, Lake reported

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These peak during dose escalation and typically resolve within 1-2 weeks at each new dose

2 The authors suggest the medications may affect inflammation and pain through mechanisms other than appetite reduction, though this needs confirmation in prospective trials

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