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[DOI] [PubMed] [Google Scholar] Salama KHA, Al-Mutawa MM

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Both insulin-like growth factor 1 (IGF-1) and insulin are potent stimulators of production of ovarian androgens, an action probably mediated by the insulin receptor [50, 51], furthermore, it is possible that the increase of circulating insulin levels potentiate the effect of luteinizing hormone (LH) on cells of the ovarian theca