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Mild nausea or gut flushing: Rare, most often in patients starting at a higher dose than recommended

1 DN is believed to be associated with neuronal, neuroglial cell and vascular endothelial cell injury caused by uncontrolled hyperglycemia, dyslipidemia and IR through multiple pathways, such as ERS, inflammation, oxidative stress and mitochondrial disorders

However, the specific role of GABA in TS and its related mechanisms remains unreported

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To the best of our knowledge, this was the first study of a potential therapy targeting the glycocalyx in sepsis to demonstrate that it can be restored by an exogenous substance (138)