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Cryotherapy presents fewer concerns about long-term use

Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, et al

Even assuming proper stratification has been achieved, any slight deviation in flow rate, liquid level, or valve control during the introduction of the regenerant can lead to acid bleeding into the anionic resin layer or alkali bleeding into the cationic resin layerat which point, the entire regeneration attempt is effectively a failure

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