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These include diabetic retinopathy (= 76, 95% CI: 18.31, 14.5823.00), retinopathy (= 56, 95% CI: 11.93, 9.1615.54), and retinal detachment (= 20, 95% CI: 1.79, 1.152.77)

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Efficacy and safety of onceweekly semaglutide versus oncedaily sitagliptin as an addon to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56week, doubleblind, phase 3a, randomised trial

Reference List FDA

However, the underlying metabolic predisposition to weight regain typically remains, which is why many clinicians recommend considering semaglutide as a long-term management strategy rather than a temporary intervention