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GHRP-2 and MK-677 may benefit from periodic breaks (4-6 weeks off every 6 months) to prevent receptor desensitization

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International consortia like the Organization for Economic Co-operation and Development (OECD) are also exploring the standardization of these systems for specific toxicological endpoints (224)

Patients with obesity are more likely to discontinue GLP-1 therapy than those with diabetes, citing lower perceived necessity, stigma, and limited coverage as key drivers 7

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