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Semaglutide was given at a dose of 2.4mg in a dose escalation manner, starting from 0.25mg once weekly subcutaneously and increasing to 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg every four weeks

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Although the drugs can effectively reduce weight and improve some metabolic indicators, they are often accompanied by a decrease in fat-free mass, and this contradiction mainly arises from the inherent differences in research models, physiological backgrounds, and intervention conditions