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Second, the study period was relatively short (24 weeks)

doi: 10.3389/fncel.2020.00226 Received 10 June 2020 Accepted 29 June 2020 Published 22 July 2020 Volume 14 - 2020 Edited by Taha A

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Accordingly, in short-term studies (19 days in duration), head-to-head comparisons in patients with T2DM have shown that when used at their therapeutic doses, sitagliptin (100 mg once daily) and saxagliptin (5 mg once daily) all achieve the same maximal and trough levels of DPP4 inhibition [84] and are associated with similar enhancements of intact incretin hormone concentrations [85,86]

Month 3 to 6: Cumulative results from multiple sessions produce the transformation phase