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MPs are recognized by the immune system either as particulate foreign bodies or via their low-molecular-weight soluble components (e.g., plasticizers, bisphenols), which mimic damage-associated molecular patterns (DAMPs)
Glutathione deficiency contributes to oxidative stress (inflammation), which plays a key role in aging and the pathogenesis of many diseases including (but not limited to)
Important parts of that cascade are also noradrenergic neurons located in the brainstem and their corresponding peripheral effectors
Statins deplete GPX4 expression and mevalonate rescues statin-induced cell death The remarkable overlap between the transcriptional changes induced by RSL3 and simvastatin in both YR1.7 and MC38 led us to question whether statins might also act on GPX4 to promote ferroptosis
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Mark Krause, the labs jovial, broad-shouldered director, walked me past dishwasher-size chromatography and mass-spectrometry machines
