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In addition, the absence of the P53 tumor suppressor gene can obstruct Gln utilization by decreasing GLS2 levels inside cells and boosting ROS levels ( 4 Targeting Gln to enhance clinical treatment of tumors The reprogramming of Gln metabolism is strongly linked to the aggressive development of tumors

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10.1016/j.metabol.2025.156191 61 StrohmeierK.HofmannM.JacakJ.NarztM.-S.WahlmuellerM.MairhoferM.et al (2022)

Oxidative damage to rhesus macaque spermatozoa results in mitotic arrest and transcript abundance changes in early embryos

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Hydrogen gas alleviates sepsis-induced brain injury by improving mitochondrial biogenesis through the activation of PGC-alpha in mice