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Naturally occurring GLP-1 is an incretin hormone that is secreted within the gastrointestinal tract upon food ingestion

Setting Realistic Expectations Counsel patients that plateaus are normal and that weight maintenance represents therapeutic success, not failure

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Nausea, constipation, or fatigue are common early side effects but typically improve as your body adapts

Based on the strength of evidence and safety boundaries, a more rational clinical positioning is to reserve GLP-1RAs as an individualized tool for intensive metabolic optimization prior to ART in refractory PCOS individuals with high BMI and prior weight-loss failure

It may occasionally help with puffiness or fluid retention, but it should not be viewed as a weight loss drug