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Ubiquitination assays comparing *NSD2 PWWP1 mutants were performed similarly, except that SKP1-FBXO22, *NSD2 PWWP1 mutants, and compounds were not incubated separately prior to the start of the reaction

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The approvalGerons first after 34 years in businesswas supported by data from the Phase III IMerge trial, in which patients on Rytelo had significantly higher rates of red blood cell transfusion independence over placebo for at least 24 weeks28% in the treatment arm versus 3% on placebo