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GtmA converts DTG to bisdethiobis(methylthio)gliotoxin (BmGT), using 2 mol SAM and resultant SAH must be re-converted to SAM via the action of the Methyl/Met cycle

Comparing their mechanisms reveals why semaglutide has demonstrated significant weight loss outcomes in clinical trials, whereas glutathione's role in weight management remains indirect and largely supportive

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