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Understanding these genetic factors can support a more informed conversation with your provider about monitoring strategies and nutritional support during treatment

Proc Natl Acad Sci USA 2010;107:878893

Why this matters: Higher doses slow digestion more aggressively Sudden appetite suppression can shock your system Increases risk of nausea, fatigue, and dizziness What to do: Follow a gradual dosage plan Stay at each dose level until your body adapts Never increase dose just to speed up weight loss Key Insight: Slower progression = fewer side effects + better long-term results 2

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Step 5: Monitor and adjust Document baseline condition before starting

If you stop the treatment, your skin color may eventually revert to its original state