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The data available to date do not suggest obvious differences in efficacy among antidotes, with the exception of a slower onset of action of sodium thiosulfate (administered alone) than of the other antidotes

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Current treatment guidelines support the use of methylcobalamin (MC), a methylated derivative of vitamin B 12 which also demonstrates efficacy in improving nerve conduction and reducing neuropathic pain 9 , but thus far, the clinical value of MC has not been studied in comparison to ALC

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N Engl J Med, 2022

Heres a practical example: You visit your GP complaining of extreme fatigue and tingling hands